DR. Mitesh Shetty
HOD and Consultant Medical Geneticist in Manipal Hospitals Bangalore.
Course Director for MSc Genomic Counselling & Fellowship in Molecular Genetic Pathology offered by Manipal Academy of Higher Education (MAHE).
Professor of Practice in Cell Biology & Molecular Genetics in Sri Devaraj Urs Academy of Higher Education and Research, Kolar
Recognized Guide for PhD in MAHE, Karnataka
I have been associated with Manipal hospitals since 2004 and currently heads the department of Medical Genetics at Manipal Hospital, Bangalore. I have more than two decades of experience in the field of field of Medical Genetics include Prenatal diagnosis, Genetic Counselling & Genetic disorders like Down syndrome, Autism,β-Thalassemia, Duchenne muscular dystrophy (DMD) & Spinal muscular atrophy(SMA), Huntington Chorea etc.
I am expertise in Genetic Counseling, Cytogenetic techniques (FISH, Karyotyping), Molecular techniques (NGS and Chromosomal Microarray), Sanger sequencing methods and Biochemical Screening.
After completing my MBBS from D.Y. Patil Medical College, University of Mumbai, I pursued masters in Medical Genetics from University of Glasgow, UK. I had trained in Clinical Genetics & Cytogenetics from the prestigious Duncan Guthrie Institute of Medical Genetics, Glasgow, U.K. Being inclined towards contributing to the research field, then later I opted to do PhD in Medical Genetics from Manipal Academy of Higher Education (MAHE).
In addition to teaching, I also recognized to be a guide for Ph.D., M.Phil. & MSc students, co-authored a chapter in the Cardiology book and Prenatal Diagnosis as well as published several papers in peer reviewed International & national journals. I have also given numerous awareness talks on Genetics at various organizations, institutes, TV and Radio talk shows, Facebook Live, etc.
Selected Training
- Master Class in IEM- Organized by Indian Society of Inborn Errors of metabolism, Pune, Jan 19
- PGS Workshop-Organized by ThermoFisher Scientific in Gurgaon, Jun 17.
- Hands-on Workshop on Analysis of Human Exome Data-Manipal University, Jan 16
- Hands-on Training on Exome and Targeted Resequencing- Manipal University, Aug 15
- Hands on Training in NGS & Bioinformatics- Manipal University, Nov 14
- Hands on training in FISH study in Cancer organized by St John Hospital B’lore, Feb 12
- Hands on training in detection of β-Thalassemia mutation at NIIH, Mumbai Jun 11
- Workshop on FISH, Comparative Genomic Hybridization (CGH) and Spectral Karyotyping (SKY) held at Department of Human Genetics, Sri Ramchandra University, Chennai, Feb 07
- Workshop on Applications of FISH in molecular cytogenetics- CHG, B’lore, Nov 05
- Workshop on Protocols in laboratory diagnosis of Inborn Metabolic disorders Hands on training programme sponsored by ICMR, NIHMANS, B’lore, Nov 04
- Hands on experience in cytogenetic department at Duncan Guthrie Institute of medical genetics, Glasgow, U.K. Aug 03
SELECTED PUBLICATIONS
- A retrospective study of the yield of next-generation sequencing in the diagnosis of developmental and epileptic encephalopathies and epileptic encephalopathies in 0-12 years aged children at a single tertiary care hospital in South India. https://pubmed.ncbi.nlm.nih.gov/38923778/
- A novel de novo heterozygous deletion at 13q14.2-q21.1 in two siblings with mild intellectual disability https://www.sciencedirect.com/science/article/pii/S2452014418300736
- Identification of Intronic-splice site mutations in GATA4 gene in Indian patients with Congenital Heart Disease. https://www.sciencedirect.com/science/article/pii/S0027510717300660
- Factor V Leiden mutation in preeclampsia – A case-control South Eastern Indian study in a tertiary care hospital https://www.sciencedirect.com/science/article/pii/S0003277817305221
- A Homozygous Missense Variant in INPP5E Associated with Joubert Syndrome and Related Disorders https://www.karger.com/Article/FullText/479673
- Association of maternal angiotensinogen gene M235T polymorphism with preeclampsia in South India: A tertiary care hospital based case-control studyhttps://www.sciencedirect.com/science/article/pii/S2214540016300949
- Pre- and Postnatal Diagnosis of 10p14 Deletion and 22q11.2 Deletion Syndrome and Significance of Non-Cardiac Markers. https://www.karger.com/Article/Abstract/446162
- Pre- and Postnatal Diagnosis of 5q35.1 and 8p23.1 Deletion in Congenital Heart Disease. https://link.springer.com/article/10.1007%2Fs12098-016-2158-3
- Pre- and Postnatal analysis of Chromosome 15q26.1 and 8p23.1 Deletions in Congenital Diaphragmatic Hernia https://www.karger.com/Article/FullText/442506
- Pre- and Postnatal Analysis of Chromosome 1q44 Deletion in Agenesis of Corpus Callosum https://www.karger.com/Article/FullText/440659
- Molecular Delineation of Partial Trisomy 14q and Partial Trisomy 12p in a Patient with Dysmorphic Features, Heart Defect and Developmental Delay https://www.karger.com/Article/Abstract/381294
- Freeman- Sheldon syndrome-Prenatal & Postnatal diagnosis https://link.springer.com/article/10.1007%2Fs12098-009-0227-6
- Novel Glioblastoma Markers with Diagnostic and Prognostic Value Identified through Transcriptome Analysis. http://clincancerres.aacrjournals.org/content/14/10/2978.long
- “Upregulation of ASCL1 and inhibition of Notch signaling Pathway characterize Progressive Astrocytoma” https://www.nature.com/articles/1208865
- CHAPTER IN BOOK-“Genetics in Congenital Heart Disease” In “A Comprehensive Approach to Congenital Heart Disease (A Lifelong Odyssey)”; Jaypee brothers, ISBN 978-93-5090-267-7
- https://books.google.co.in/books?id=b_QbioaHT0MC&pg=PR17&source=gbs_selected_pages&cad=3#v=onepage&q&f=false
SELECTED TALKS
- “Lessons learned from Exome Sequencing & Cell-Free DNA” in Essential of Genetics in Obstetric Practice organized by Society of Maternal Fetal Medicine, B’lore, Dec 18.
- “Panel Discussion: Genetic Screening-A case based approach” in LIFE 2018-Infertility & Fetal Medicine organized by IIRRH.
- “Prenatal genetic diagnosis: medical facts about the diagnosis, the probable course of the disorder, and available management” in the Genetics Workshop organized by NIMHANS, Apr 18.
- “Genetic Counselling Training with special emphasis on Prenatal, Postnatal Diagnosis & Reproductive Genetics” conducted at Ramaiah Medical College, Feb 18.
- “Indications & counselling for PGD & PGS” in the PGS workshop at IAEHC, Dr Sulochana Gunasheela Memorial Conference, Oct 17.
- “Genetics of Recurrent Implantation Failures & Recurrent Pregnancy loss” Organized by Milann IVF centre Jun 17.
- “Lab Diagnosis in Genetic Disorders” in 38th CME in Internal Medicine organized by Association of Physicians of India & Medical Education and Research Trust, B’lore Oct 16.
- “Advances in Medical Genetics” in 43rd Annual conference of Karnataka Chapter of Indian Association of Pathologists & Microbiologists KAPCON, SDM Dharwad, Aug 16.
- “GENES AS TARGET IN CANCER” in Pharmacogenomics, SDUMC, Kolar, Aug 16.
- “Biochemical Screening in Pregnancy” in CME on ‘‘Laboratories’ Perspective on Women’s Health” organized by St. John’s Medical College & RGUHS, Nov 15.
- “Preventive Gynae Oncology” panel Discussion organized by BSOG at API Bhuvan, Sep14.
- “Non-invasive Prenatal Diagnosis” in MUSKCON 2014 organised by Medical Ultrasound Society of Karnataka, Apr 14.
- “Molecular genetics of renal cell carcinoma” in instructional course on renal cell carcinoma organized by Karnataka Urology Association at Victoria Hospital Campus, Dec 12.